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Innovative diagnostics against antimicrobial resistance

About US

We are a life science-start-up that set out as a spin-off from SciLifeLab/Karolinska Institutet. Based on our work on microbial metadegradomics  we aim to increase  efficiency, safety and speed in the development of small molecules modulating the microbiome. Our technology provides  immediate information of the effect of new drug substances on the microbiome.

Currently, our team focus on the application of this technology to measure cellular growth at the molecular level and to speed up the diagnosis of phenotypic antimicrobial resistance .

Our mission

The rapid emergence of antibiotic-resistant bacteria and multidrug-resistant pathogenic fungi pose a threat to global health. If no urgent actions are taken, by 2050, antimicrobial resistance (AMR) will cause an estimated loss of 10 million lives and $US100 trillion. Fast and accurate diagnosis of antimicrobial resistant strains is key to contain the rise of AMR, limit its spread and provide adequate treatment to patients.

At 3N Bio we work on the development of quick and simple tests able to detect antimicrobial resistance independent of the drug resistance mechanism used. We aim to provide fast diagnosis for bacterial infections and provide actionable recommendation for antibiotic usage. Our final goal is to  accelerate diagnosis,  improve patient survival, and contribute to individualized and rational use of antibiotics.

TEAM

Susanne HUCH, PhD

Co-founder, CEO

Ryan Hull, PhD

COO

LILIT NERSISYAN, PHD

Co-founder

VICENT PELECHANO, PHD

Co-founder, Chairman

Our technology

We have discovered that by studying how bacterial cells recycle  the mRNAs encoding for proteins, we can obtain direct information regarding protein synthesis and cell growths. Our team is leveraging those RNA degradation signatures to obtain fast information regarding specie-specific response to drugs and antibiotic treatments. Importantly, all that can be done in complex microbial samples without the need for cell culture, bacteria isolation  or any complex experimental procedures. Our team is is leveraging the use of RNA degradation signatures to provide fast and accurate information of bacterial growth at molecular level.

References:

Huch, S., Nersisyan, L.  et al. Atlas of mRNA translation and decay for bacteria. Nat Microbiol (2023). https://doi.org/10.1038/s41564-023-01393-z

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Location
Solna, Sweden
info@3n-bio.com